Investigating how KSHV DNA replication proteins work
Single Molecule analysis of KSHV/HHV8 DNA replication proteins
['FUNDING_OTHER'] · NORTH CAROLINA CENTRAL UNIVERSITY · NIH-11063192
This study is looking at how certain proteins from the KSHV virus work together, with the hope of finding new ways to create treatments for people affected by this virus, which is linked to some cancers and AIDS-related issues.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NORTH CAROLINA CENTRAL UNIVERSITY (nih funded) |
| Locations | 1 site (DURHAM, UNITED STATES) |
| Trial ID | NIH-11063192 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the molecular interactions of proteins involved in the replication of KSHV, a virus linked to certain cancers and AIDS-related conditions. Using advanced electron microscopy, the study aims to visualize and characterize the functions of specific viral proteins and their interactions with DNA. By identifying these interactions, the research seeks to discover new antiviral targets that could lead to effective treatments for KSHV infections. Patients may benefit from insights that could inform the development of novel antiviral therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals infected with KSHV or those at risk for KSHV-related diseases.
Not a fit: Patients who do not have KSHV infections or related conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new antiviral treatments for KSHV infections.
How similar studies have performed: Previous research has shown promise in targeting viral proteins for antiviral development, suggesting that this approach could yield valuable insights.
Where this research is happening
DURHAM, UNITED STATES
- NORTH CAROLINA CENTRAL UNIVERSITY — DURHAM, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: COSTANTINI, LINDSEY M — NORTH CAROLINA CENTRAL UNIVERSITY
- Study coordinator: COSTANTINI, LINDSEY M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome Virus