Investigating how KSHV DNA replication proteins work
Official title: Single Molecule analysis of KSHV/HHV8 DNA replication proteins
Funded at North Carolina Central University · NIH-11063192 · Data updated 2026-11-12
This study is looking at how certain proteins from the KSHV virus work together, with the hope of finding new ways to create treatments for people affected by this virus, which is linked to some cancers and AIDS-related issues.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | North Carolina Central University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project start | April 1, 2024 |
| Project end | February 29, 2028 |
| Funding year | 2025 |
| Award (this year) | $135,000 |
| NIH project number | 5R16GM153198-02 |
| Project ID | NIH-11063192 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals infected with KSHV or those at risk for KSHV-related diseases.
✕Less likely to help
Patients who do not have KSHV infections or related conditions may not benefit from this research.
What this research studies
This research focuses on understanding the molecular interactions of proteins involved in the replication of KSHV, a virus linked to certain cancers and AIDS-related conditions. Using advanced electron microscopy, the study aims to visualize and characterize the functions of specific viral proteins and their interactions with DNA. By identifying these interactions, the research seeks to discover new antiviral targets that could lead to effective treatments for KSHV infections. Patients may benefit from insights that could inform the development of novel antiviral therapies.
Why it matters
Potential benefit: If successful, this research could lead to the development of new antiviral treatments for KSHV infections.
How similar studies have gone: Previous research has shown promise in targeting viral proteins for antiviral development, suggesting that this approach could yield valuable insights.
Where this research is happening
-
North Carolina Central University
Durham, United States Active
Researchers
- Principal investigator: Costantini, Lindsey M — North Carolina Central University
- Study coordinator: Costantini, Lindsey M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.