Investigating how Kratom and Cannabis compounds affect neuropathic pain

Kratom and Cannabinoid Constituents: Mechanisms and Interactive Effects in Neuropathic Pain

NIH-funded research Temple Univ of the Commonwealth · NIH-10745835

This study is looking at how Kratom and Cannabis might work together to help people with nerve pain and anxiety, so if you're interested in natural alternatives to opioids, this research could offer some helpful insights for safer pain relief.

Quick facts

Grant typeR21 grant
Study typeNIH-funded research
Funding institutionTemple Univ of the Commonwealth NIH-funded
Lab location1 site (Philadelphia, United States)
Project IDNIH-10745835 on NIH RePORTER

What this research studies

This research explores the potential interactions between Kratom and Cannabis compounds, particularly focusing on their effects on neuropathic pain and anxiety. It aims to understand the unique and shared pharmacological actions of these natural remedies, which are increasingly sought after by patients looking for alternatives to opioids. The study will involve laboratory experiments to assess how these compounds may work together and their implications for efficacy and side effects. By examining these interactions, the research hopes to provide insights into safer pain management options for patients.

Who could benefit from this research

Good fit: Ideal candidates for this research are individuals suffering from chronic pain or anxiety who are seeking alternative treatments.

Not a fit: Patients who are not experiencing chronic pain or anxiety may not receive any benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to safer and more effective treatment options for chronic pain and anxiety, potentially reducing reliance on opioids.

How similar studies have performed: While there has been increasing interest in the therapeutic use of Cannabis, this specific investigation into the interactions between Kratom and Cannabis is novel and has not been extensively studied.

Where this research is happening

Philadelphia, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.