Investigating how kidney tubules communicate with glomeruli in kidney disease
The Role of MCP-1 in Tubular-to-Glomerular Crosstalk in Proteinuric Kidney Disease
This study is looking at how a protein called MCP-1 affects communication between different parts of the kidney, especially in people with chronic kidney disease, to better understand why kidney damage happens and how we might find new ways to help.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-11081665 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of a protein called MCP-1 in the communication between kidney tubules and glomeruli, particularly in the context of chronic kidney disease (CKD). The study will explore how injury to kidney tubules can lead to protein leakage into urine, a condition known as proteinuria, which worsens kidney health. By using specialized mouse models, researchers will examine the mechanisms by which tubules influence glomerular function and contribute to kidney damage. The findings could provide insights into new therapeutic targets for CKD.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with chronic kidney disease, particularly those experiencing proteinuria.
Not a fit: Patients with acute kidney injury or those without chronic kidney disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent or slow the progression of chronic kidney disease.
How similar studies have performed: Previous research has shown promising results in understanding kidney disease mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Bondi, Corry Dominic — University of Pittsburgh at Pittsburgh
- Study coordinator: Bondi, Corry Dominic
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.