Investigating how kidney-produced vasopressin affects kidney disease progression
Official title: Understanding the physiology and pathophysiology of kidney-derived vasopressin
Funded at Vanderbilt University Medical Center · NIH-11062464 · Data updated 2026-11-12
This study is looking at how a hormone called vasopressin, which is usually made in the brain, also affects kidney health and the growth of cysts in people with chronic kidney disease and polycystic kidney disease, with the hope of finding new ways to help manage these conditions.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project start | April 1, 2023 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $158,436 |
| NIH project number | 5K08DK135931-03 |
| Project ID | NIH-11062464 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults diagnosed with chronic kidney disease or polycystic kidney disease.
✕Less likely to help
Patients with acute kidney injury or those without chronic kidney disease may not benefit from this research.
What this research studies
This research focuses on understanding the role of vasopressin, a hormone traditionally thought to be produced only in the brain, in the progression of chronic kidney disease (CKD) and polycystic kidney disease (PKD). The researchers aim to explore how vasopressin produced in the kidneys influences water balance and contributes to cyst growth in PKD. By studying both human and mouse models, they will investigate the mechanisms behind kidney-derived vasopressin and its impact on kidney health. This work could lead to new therapeutic strategies for managing CKD and PKD.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that slow the progression of chronic kidney disease and improve patient outcomes.
How similar studies have gone: Previous research has shown promising results in understanding the role of vasopressin in kidney disease, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Vanderbilt University Medical Center
Nashville, United States Active
Researchers
- Principal investigator: Arroyo Ornelas, Juan Pablo — Vanderbilt University Medical Center
- Study coordinator: Arroyo Ornelas, Juan Pablo
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.