Investigating how kidney inflammation affects high blood pressure related to salt intake
Role of pressure induced renal inflammation in salt-sensitive hypertension
This study is looking at how kidney inflammation caused by protein in the urine might make high blood pressure worse for people who are sensitive to salt, and it hopes to find new ways to help manage this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project ID | NIH-10828802 on NIH RePORTER |
What this research studies
This research explores the connection between kidney inflammation and salt-sensitive hypertension, a condition where blood pressure rises in response to salt. It focuses on understanding how protein in the urine triggers inflammation in the kidneys and how this inflammation may worsen high blood pressure. The study uses animal models to investigate the role of specific immune cells and chemokines in this process, aiming to identify potential new treatments that could help manage hypertension more effectively.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with salt-sensitive hypertension, particularly those showing signs of kidney inflammation.
Not a fit: Patients with hypertension that is not influenced by salt intake or those without kidney-related issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for managing high blood pressure, particularly in patients who are sensitive to salt.
How similar studies have performed: Previous research has indicated that targeting immune responses in hypertension may be effective, suggesting that this approach could yield promising results.
Where this research is happening
Minneapolis, United States
- University of Minnesota — Minneapolis, United States (Active)
Researchers
- Principal investigator: Evans, Louise Christine — University of Minnesota
- Study coordinator: Evans, Louise Christine
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.