Investigating how kidney immune cells affect blood pressure in hypertension
Official title: Sympathetic Activation of Renal Dendritic Cells in Hypertension
Funded at University of Utah · NIH-11010768 · Data updated 2026-11-12
This study is looking at how certain immune cells in the kidneys might affect high blood pressure, especially in people who are sensitive to salt, and it aims to find out how these cells interact with the nervous system to influence blood pressure and kidney function.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project start | January 17, 2024 |
| Project end | December 31, 2025 |
| Funding year | 2025 |
| Award (this year) | $103,950 |
| NIH project number | 5R03DK138251-02 |
| Project ID | NIH-11010768 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with hypertension, especially those who are salt-sensitive.
✕Less likely to help
Patients with hypertension that is not influenced by salt intake or those with other unrelated health conditions may not benefit from this research.
What this research studies
This research explores the role of renal dendritic cells in hypertension, particularly how their activation by the sympathetic nervous system influences sodium transport and blood pressure regulation. By examining the interaction between these immune cells and cytokines, the study aims to uncover mechanisms that contribute to salt-sensitive hypertension. The approach includes using animal models to analyze changes in kidney function and blood pressure in response to specific treatments. This could lead to a better understanding of how inflammation and immune responses impact hypertension.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for managing hypertension, particularly in patients with salt-sensitive conditions.
How similar studies have gone: Previous research has shown promising results in understanding the role of immune cells in hypertension, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Utah
Salt Lake City, United States Active
Researchers
- Principal investigator: Wynne, Brandi Michele — University of Utah
- Study coordinator: Wynne, Brandi Michele
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.