Investigating how kidney cysts can be reversed in a genetic kidney disease
Polycystin Dependent Mechanisms of Tubular Plasticity
This study is looking at a genetic kidney condition called ADPKD and is testing if fixing the genes that cause kidney cysts in mice can help restore normal kidney function, which could lead to better treatments for people with this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-10643823 on NIH RePORTER |
What this research studies
This research focuses on autosomal dominant polycystic kidney disease (ADPKD), a genetic condition that leads to the formation of cysts in the kidneys. The study uses advanced mouse models to explore whether reversing the genetic mutations responsible for cyst formation can restore normal kidney function. By employing innovative techniques to reactivate the genes involved, researchers aim to determine the potential for reversing kidney damage and improving health outcomes. This work could provide insights into the timing and effectiveness of therapeutic interventions for patients with ADPKD.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with autosomal dominant polycystic kidney disease, particularly those experiencing early stages of kidney cyst formation.
Not a fit: Patients with advanced kidney disease or those who do not have a genetic basis for their kidney condition may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that reverse kidney damage and improve kidney function in patients with ADPKD.
How similar studies have performed: Other research has shown promising results in reversing kidney damage in animal models, indicating potential for success in similar therapeutic approaches.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Somlo, Stefan — Yale University
- Study coordinator: Somlo, Stefan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.