Investigating how kidney cells respond to a hormone that regulates blood pressure
Renal Pericytes as a Target for Angiotensin II Signaling in Hypertension
This study is looking at how certain kidney cells respond to a hormone that helps control blood pressure, which could give us new ideas for treating high blood pressure and protecting kidney health.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Southern California NIH-funded |
| Lab location | 1 site (Los Angeles, UNITED STATES) |
| Project ID | NIH-11082126 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of renal pericytes, a specific type of kidney cell, in the signaling pathways of angiotensin II, a hormone that plays a crucial role in blood pressure regulation. By examining how these cells respond to angiotensin II, the research aims to uncover new insights into the mechanisms of hypertension and how it affects kidney function. The approach includes analyzing single-cell RNA sequencing data to identify the expression of angiotensin receptors in pericytes and conducting experiments to explore their specific roles in blood pressure regulation. This could lead to a better understanding of hypertension and potential new treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with hypertension or related kidney conditions.
Not a fit: Patients without hypertension or kidney-related issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic targets for managing hypertension and improving kidney health.
How similar studies have performed: Previous research has shown promising results in targeting angiotensin signaling pathways for hypertension treatment, indicating that this approach has potential for success.
Where this research is happening
Los Angeles, UNITED STATES
- University of Southern California — Los Angeles, United States (Active)
Researchers
- Principal investigator: Nelson, Jonathan W — University of Southern California
- Study coordinator: Nelson, Jonathan W
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.