Investigating how kidney cells interact to influence cyst growth in a genetic kidney disease
Official title: Pathogenic reciprocal interplay between cyst epithelium and myofibroblasts in polycystic kidney disease
Funded at University of Kansas Medical Center · NIH-10978216 · Data updated 2026-11-12
This study is looking at how certain kidney cells called myofibroblasts might help cysts grow in people with autosomal dominant polycystic kidney disease (ADPKD), and it will test if reducing these cells can slow down that growth, which could lead to new ways to treat the condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kansas Medical Center NIH-funded |
| Lab location | 1 site (Kansas City, United States) |
| Project start | February 1, 2023 |
| Project end | November 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $433,227 |
| NIH project number | 5R01DK135308-03 |
| Project ID | NIH-10978216 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with autosomal dominant polycystic kidney disease (ADPKD).
✕Less likely to help
Patients without a diagnosis of ADPKD or those with other unrelated kidney conditions may not benefit from this research.
What this research studies
This research focuses on understanding the role of myofibroblasts, a type of kidney cell, in the progression of autosomal dominant polycystic kidney disease (ADPKD). The study aims to explore how these cells undergo a process called autophagy and release nutrients that may promote the growth of cysts in the kidneys. By using advanced mouse models, the researchers will test whether reducing the number of myofibroblasts can slow down cyst growth and examine the specific mechanisms involved in this process. This research could provide insights into new therapeutic strategies for managing ADPKD.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that slow the progression of cyst growth in patients with ADPKD.
How similar studies have gone: Previous research has shown promising results in understanding the role of myofibroblasts in kidney diseases, suggesting that this approach may yield significant insights.
Where this research is happening
-
University of Kansas Medical Center
Kansas City, United States Active
Researchers
- Principal investigator: Rao, Reena — University of Kansas Medical Center
- Study coordinator: Rao, Reena
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.