Investigating how kidney cells help control blood pressure
The role of kidney epithelial cells specific EP4 receptors in blood pressure control
This study is looking at how certain receptors in kidney cells might help control blood pressure, with the hope that what we learn could lead to better treatments for people with high blood pressure.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-11113971 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of specific receptors in kidney cells that may help regulate blood pressure. By studying how these receptors interact with hormones and sodium channels in the kidneys, the research aims to uncover new mechanisms that contribute to hypertension. The approach involves advanced techniques such as genetic manipulation in animal models to observe changes in blood pressure and kidney function. Patients may benefit from insights that could lead to new treatments for high blood pressure.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who are experiencing hypertension.
Not a fit: Patients with normal blood pressure or those whose hypertension is not related to kidney function may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic targets for managing hypertension more effectively.
How similar studies have performed: Previous research has shown promising results in understanding the role of kidney receptors in blood pressure regulation, indicating that this approach has potential for success.
Where this research is happening
Durham, United States
- Duke University — Durham, United States (Active)
Researchers
- Principal investigator: Yang, Ting — Duke University
- Study coordinator: Yang, Ting
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.