Investigating how JMJD1A modifications affect prostate cancer resistance to treatment
Role of JMJD1A modifications in castration resistance of prostate cancer
This study is looking at a protein called JMJD1A to see how it affects the growth of advanced prostate cancer that doesn't respond to hormone therapy, with the hope of finding new ways to improve treatment for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Maryland Baltimore NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10851789 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of JMJD1A, a histone demethylase, in the progression of castration-resistant prostate cancer (CRPC) and neuroendocrine prostate cancer (NEPC). The study aims to explore how modifications to JMJD1A influence its stability and activity, particularly in relation to the androgen receptor pathway and the N-Myc oncoprotein. By identifying the mechanisms that regulate JMJD1A, the research seeks to develop potential therapeutic strategies targeting this protein to improve treatment outcomes for patients with advanced prostate cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are men diagnosed with castration-resistant prostate cancer or neuroendocrine prostate cancer.
Not a fit: Patients with early-stage prostate cancer or those who have not undergone castration therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options that effectively target castration-resistant prostate cancer, potentially improving survival rates and quality of life for patients.
How similar studies have performed: Previous research has shown promising results in targeting similar pathways in prostate cancer, indicating potential for success in this approach.
Where this research is happening
Baltimore, United States
- University of Maryland Baltimore — Baltimore, United States (Active)
Researchers
- Principal investigator: Qi, Jianfei — University of Maryland Baltimore
- Study coordinator: Qi, Jianfei
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.