Investigating how itaconate affects inflammatory blood cell accumulation to prevent anemia
Itaconate mediated control of inflammatory hemophagocyte accumulation
['FUNDING_FELLOWSHIP'] · UNIVERSITY OF WASHINGTON · NIH-11078658
This study is looking at how a substance called itaconate, made by an enzyme named IRG1, helps manage certain immune cells that can cause severe anemia, with the goal of finding new ways to treat anemia linked to inflammation.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF WASHINGTON (nih funded) |
| Locations | 1 site (SEATTLE, UNITED STATES) |
| Trial ID | NIH-11078658 on ClinicalTrials.gov |
What this research studies
This research explores the role of the enzyme IRG1 and its product, itaconate, in controlling inflammatory blood cells that can lead to severe anemia. By understanding how itaconate influences the behavior of specific immune cells, the study aims to restore the balance between red blood cell production and clearance during inflammation. The research employs mouse models to examine the transition of monocytes into specialized inflammatory hemophagocytes, which are implicated in the development of anemia. This could provide insights into new therapeutic strategies for managing anemia associated with inflammatory conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from severe anemia related to chronic inflammatory conditions.
Not a fit: Patients with anemia not associated with inflammation or those with other unrelated blood disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent or alleviate severe anemia in patients with inflammatory diseases.
How similar studies have performed: While the specific mechanisms of itaconate in this context are still being explored, similar approaches targeting inflammatory processes have shown promise in other studies.
Where this research is happening
SEATTLE, UNITED STATES
- UNIVERSITY OF WASHINGTON — SEATTLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LICHAUCO, KATRINA — UNIVERSITY OF WASHINGTON
- Study coordinator: LICHAUCO, KATRINA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Anemia due to Chronic Disorder, anemia of chronic disease