Investigating how isoflurane may protect the brain after a hemorrhagic stroke.
Molecular mechanisms underlying isoflurane conditioning-induced neurovascular protection in subarachnoid hemorrhage
This study is looking at how a common anesthetic called isoflurane might help protect the brain after a serious condition called aneurysmal subarachnoid hemorrhage, and it's using animal models to find out how it works so that new treatments can be developed for people with brain injuries.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-10849790 on NIH RePORTER |
What this research studies
This research focuses on understanding how isoflurane, an anesthetic, can provide neurovascular protection in cases of aneurysmal subarachnoid hemorrhage (SAH). The study involves using animal models to explore the molecular mechanisms behind this protective effect and aims to develop new therapeutic strategies based on these findings. Researchers will employ various techniques, including immunohistochemistry and optical imaging, to assess brain function and outcomes after SAH. The ultimate goal is to translate these insights into potential treatments for patients suffering from brain injuries.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced an aneurysmal subarachnoid hemorrhage or are at risk for such brain injuries.
Not a fit: Patients with other types of brain injuries not related to subarachnoid hemorrhage may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that significantly improve recovery and outcomes for patients who experience aneurysmal subarachnoid hemorrhage.
How similar studies have performed: While the specific approach of using isoflurane for neurovascular protection in SAH is novel, similar anesthetic conditioning strategies have shown promise in other contexts.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Athiraman, Umeshkumar — Washington University
- Study coordinator: Athiraman, Umeshkumar
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.