Investigating how iron levels affect movement and health in older adults
Functional Decline in Low Functioning Older Adults; Role of iron dysregulation
This study is looking at how problems with iron and tiny energy factories in our cells might affect the health and movement of older adults who are not very active, with the goal of finding ways to help them feel better and live more comfortably.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project ID | NIH-10887637 on NIH RePORTER |
What this research studies
This research focuses on understanding the biological mechanisms behind rapid functional decline in low-functioning older adults. It examines the role of mitochondria and iron transport in cellular health, which may contribute to physical disabilities. By studying how iron dysregulation impacts muscle function and overall health, the research aims to identify potential therapeutic targets to improve the quality of life for older adults. Participants may undergo assessments related to their muscle function and iron levels.
Who could benefit from this research
Good fit: Ideal candidates are older adults aged 65 and above who are experiencing low functional capacity.
Not a fit: Patients who are high-functioning and do not exhibit any signs of functional decline may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that help preserve mobility and independence in older adults.
How similar studies have performed: Previous research has shown that addressing mitochondrial dysfunction can lead to improvements in physical health, suggesting potential for success in this area.
Where this research is happening
Gainesville, United States
- University of Florida — Gainesville, United States (Active)
Researchers
- Principal investigator: Leeuwenburgh, Christiaan — University of Florida
- Study coordinator: Leeuwenburgh, Christiaan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.