Investigating how iron levels affect mental health in people with HIV.
Iron Dysregulation and Neuropsychiatric Complications of HIV Across the Lifespan: Impact of Biologic Factors, Antiretroviral Therapy and Genetics
This study is looking at how problems with iron in the body might affect mental health, like depression and thinking skills, in people living with HIV, especially considering differences between men and women, and it may involve giving some blood and spinal fluid samples to help us understand this better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-11001981 on NIH RePORTER |
What this research studies
This research explores the connection between iron dysregulation and neuropsychiatric issues, such as depression and cognitive impairment, in individuals living with HIV. By analyzing data from large cohort studies, the research aims to uncover the biological mechanisms that contribute to these mental health challenges, particularly focusing on differences between sexes. The study will utilize various biomarkers and genetic information to assess how iron metabolism influences mental health outcomes. Patients may be asked to provide blood and cerebrospinal fluid samples for analysis.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals living with HIV who are experiencing symptoms of depression or cognitive impairment.
Not a fit: Patients without HIV or those not experiencing neuropsychiatric symptoms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved mental health treatments for individuals with HIV by addressing iron dysregulation.
How similar studies have performed: Previous research has indicated a link between iron metabolism and mental health, suggesting that this approach may yield valuable insights.
Where this research is happening
Cleveland, United States
- Cleveland Clinic Lerner Com-Cwru — Cleveland, United States (Active)
Researchers
- Principal investigator: Kallianpur, Asha R — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: Kallianpur, Asha R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.