Investigating how iron buildup affects brain implants and how to protect against it
Effects of Iron Accumulation in Intracortical Implants and Protection by Iron Chelation
['FUNDING_R01'] · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · NIH-11061907
This study is looking at how too much iron in the brain from tiny implants can cause problems, and it will test a medication called deferasirox to see if it can help reduce the iron and make the implants work better for people who need them.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MIAMI SCHOOL OF MEDICINE (nih funded) |
| Locations | 1 site (CORAL GABLES, UNITED STATES) |
| Trial ID | NIH-11061907 on ClinicalTrials.gov |
What this research studies
This research focuses on the effects of iron accumulation in the brain caused by microelectrodes (ME) implanted for neurophysiological applications. It aims to understand how excess iron leads to oxidative stress and inflammation, which can impair the functionality of these implants. The researchers will explore the use of an iron chelator, deferasirox, to reduce iron levels and improve the long-term performance of these devices. By employing various techniques, including transcriptomics, they will assess the inflammatory responses in brain tissue surrounding the implants.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with motor disabilities who may benefit from neuroprosthetic devices or brain-computer interfaces.
Not a fit: Patients without motor disabilities or those who do not require implanted neurotechnology may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance the effectiveness and longevity of brain implants used in treating motor disabilities.
How similar studies have performed: Previous research has shown that addressing oxidative stress and inflammation can improve the performance of neural implants, suggesting a promising avenue for this approach.
Where this research is happening
CORAL GABLES, UNITED STATES
- UNIVERSITY OF MIAMI SCHOOL OF MEDICINE — CORAL GABLES, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PRASAD, ABHISHEK — UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
- Study coordinator: PRASAD, ABHISHEK
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired brain injury