Investigating how iron and calcium interact in heart cells
Ferroptosis in the Heart: Iron Calcium Crosstalk and Compartmentalization
['FUNDING_R01'] · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · NIH-10983794
This study looks at how iron and calcium work together in heart cells and how problems with these minerals can harm the heart, especially for people with conditions like hereditary hemochromatosis and beta thalassemia, to help find better ways to treat heart issues.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | RUTGERS BIOMEDICAL AND HEALTH SCIENCES (nih funded) |
| Locations | 1 site (Newark, UNITED STATES) |
| Trial ID | NIH-10983794 on ClinicalTrials.gov |
What this research studies
This research explores the relationship between iron and calcium in heart cells, particularly how their interaction can lead to heart damage. It focuses on conditions like hereditary hemochromatosis and beta thalassemia, where iron accumulation occurs due to genetic factors or repeated blood transfusions. By studying these mechanisms, the research aims to uncover how disruptions in iron and calcium levels contribute to heart diseases, potentially leading to new treatment strategies. The approach includes using animal models to better understand the cellular processes involved in cardiac dysfunction.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with genetic disorders that cause iron accumulation in the heart, such as hereditary hemochromatosis or beta thalassemia.
Not a fit: Patients without iron overload conditions or those with unrelated heart diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for heart conditions caused by iron overload.
How similar studies have performed: Previous research has indicated that understanding the interplay between iron and calcium in heart cells could lead to significant advancements in treating related cardiac conditions.
Where this research is happening
Newark, UNITED STATES
- RUTGERS BIOMEDICAL AND HEALTH SCIENCES — Newark, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: XIE, LAI-HUA — RUTGERS BIOMEDICAL AND HEALTH SCIENCES
- Study coordinator: XIE, LAI-HUA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.