Investigating how iron affects oxidative stress and Alzheimer's biomarkers in older adults
The effects of iron on oxidative stress and Alzheimer's biomarkers in amyloid-positive and negative elderly normal
['FUNDING_R01'] · WEILL MEDICAL COLL OF CORNELL UNIV · NIH-10840391
This study is looking at how iron levels in the body might affect brain health in older adults with Alzheimer's disease, especially comparing those with and without certain brain plaques, to help find new ways to support cognitive function.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WEILL MEDICAL COLL OF CORNELL UNIV (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-10840391 on ClinicalTrials.gov |
What this research studies
This research explores the relationship between iron levels and Alzheimer's disease (AD) in elderly individuals, particularly focusing on those with and without beta-amyloid plaques. By utilizing advanced imaging techniques like magnetic resonance imaging (MRI) and analyzing cerebrospinal fluid (CSF) markers, the study aims to uncover how iron may contribute to cognitive decline associated with AD. The research involves a prospective analysis of 80 elderly participants, half of whom will show evidence of amyloid deposition, to determine the impact of iron on brain health and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are elderly individuals, particularly those who are amyloid-positive as indicated by PET scans.
Not a fit: Patients who do not have evidence of amyloid plaques or are not elderly may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that target iron levels to slow or prevent the progression of Alzheimer's disease.
How similar studies have performed: Previous studies have indicated a potential link between iron accumulation and cognitive decline in Alzheimer's, suggesting that this approach may yield valuable insights.
Where this research is happening
NEW YORK, UNITED STATES
- WEILL MEDICAL COLL OF CORNELL UNIV — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHIANG, GLORIA CHIA-YI — WEILL MEDICAL COLL OF CORNELL UNIV
- Study coordinator: CHIANG, GLORIA CHIA-YI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia