Investigating how irisin affects immune response and fat tissue
Official title: The mechanistic study on irisin-mediated immune response and its role in adipose tissue dynamics
Funded at Dana-Farber Cancer Inst · NIH-11032318 · Data updated 2026-11-12
This study is looking at how a hormone called irisin, which is released when we exercise, affects our immune system and fat tissue, with the hope of finding new ways to help people with obesity and related health issues like type II diabetes and Alzheimer's disease.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Dana-Farber Cancer Inst NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | January 1, 2025 |
| Project end | November 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $152,454 |
| NIH project number | 1K01DK141969-01 |
| Project ID | NIH-11032318 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals struggling with obesity, type II diabetes, or cognitive decline associated with Alzheimer's disease.
✕Less likely to help
Patients who are not affected by obesity or metabolic disorders may not benefit from this research.
What this research studies
This research explores the role of irisin, a hormone released during exercise, in regulating immune responses and its effects on fat tissue dynamics. By examining how irisin influences inflammation in adipose tissue, the study aims to uncover mechanisms that could help combat obesity and related metabolic disorders. The research involves collaboration with experts to analyze specific immune pathways and their interactions with irisin, potentially leading to new therapeutic strategies for conditions like type II diabetes and Alzheimer's disease.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for obesity and metabolic disorders, improving overall health and quality of life for patients.
How similar studies have gone: Previous research has shown promising results in understanding the role of exercise-induced hormones like irisin in metabolic health, indicating a potential for success in this area.
Where this research is happening
-
Dana-Farber Cancer Inst
Boston, United States Active
Researchers
- Principal investigator: A, Mu — Dana-Farber Cancer Inst
- Study coordinator: A, Mu
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.