Investigating how IRE1α affects lung tissue in fibrosis
IRE1α mediated dysregulation of the pulmonary epithelium in lung fibrosis
['FUNDING_CAREER'] · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · NIH-11035123
This study is looking at how a protein called IRE1α affects lung health in people with idiopathic pulmonary fibrosis (IPF) and aims to find new ways to treat this condition by using special compounds that block its activity.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN FRANCISCO (nih funded) |
| Locations | 1 site (SAN FRANCISCO, UNITED STATES) |
| Trial ID | NIH-11035123 on ClinicalTrials.gov |
What this research studies
This research focuses on idiopathic pulmonary fibrosis (IPF), a progressive lung disease that leads to severe respiratory issues. It examines the role of IRE1α, a protein involved in managing stress within cells, particularly in the lungs. The study aims to understand how IRE1α contributes to cell death and fibrosis in lung tissue, using specialized compounds that inhibit its functions. By analyzing lung samples from both mice and humans, the research seeks to uncover new pathways that could be targeted for treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with idiopathic pulmonary fibrosis or those experiencing significant lung fibrosis.
Not a fit: Patients with lung conditions unrelated to fibrosis or those who do not have significant lung impairment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that prevent or reverse lung fibrosis, improving the quality of life for patients with IPF.
How similar studies have performed: Previous research has shown promising results with similar approaches targeting the IRE1α pathway in animal models, indicating potential for success in human applications.
Where this research is happening
SAN FRANCISCO, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN FRANCISCO — SAN FRANCISCO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: AUYEUNG, VINCENT CHURK-MAN — UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- Study coordinator: AUYEUNG, VINCENT CHURK-MAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.