Investigating how IP3 receptors affect heart cell function
Functional role of IP3 receptors in the regulation of cardiac myofibroblasts
This study is looking at how certain receptors in heart cells called IP3Rs affect the healing process after heart injuries, which could help us find new ways to treat heart failure.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Albert Einstein College of Medicine NIH-funded |
| Lab location | 1 site (Bronx, United States) |
| Project ID | NIH-10650161 on NIH RePORTER |
What this research studies
This research explores the role of inositol 1,4,5-trisphosphate receptors (IP3Rs) in cardiac myofibroblasts, which are important cells in the heart that contribute to conditions like heart failure. The study aims to understand how these receptors influence the activation of cardiac fibroblasts after heart injury, using various experimental methods including in vivo, ex vivo, and in vitro approaches. By examining the changes in IP3R expression in these cells, the research seeks to uncover new insights into heart disease mechanisms and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults with a history of myocardial infarction or heart arrhythmias.
Not a fit: Patients without cardiovascular disorders or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for heart failure and related cardiovascular diseases.
How similar studies have performed: While the role of IP3Rs in cardiomyocytes has been studied, this specific investigation into their function in cardiac fibroblasts is novel and has not been extensively tested.
Where this research is happening
Bronx, United States
- Albert Einstein College of Medicine — Bronx, United States (Active)
Researchers
- Principal investigator: Santulli, Gaetano — Albert Einstein College of Medicine
- Study coordinator: Santulli, Gaetano
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.