Investigating how ion channels interact with transporters in cells
Ion Channel Transporter Interactions
This study is looking at how certain proteins in our cells work together to help transport important molecules, and it hopes to find new treatments that could help people with conditions like ataxia, heart rhythm problems, and diabetes.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project ID | NIH-11061040 on NIH RePORTER |
What this research studies
This research explores the interactions between voltage-gated potassium channels and sodium-coupled solute transporters, which are crucial for transporting various molecules across cell membranes. The team will study how these channels and transporters form complexes that regulate cellular signaling and electrical activity. By examining these interactions, the research aims to identify new small-molecule modulators that could have therapeutic potential for various disorders. Patients may benefit from insights into how disruptions in these channels contribute to conditions like ataxia, cardiac arrhythmia, and diabetes.
Who could benefit from this research
Good fit: Ideal candidates include individuals with conditions such as ataxia, cardiac arrhythmia, diabetes, and other related disorders.
Not a fit: Patients with conditions unrelated to ion channel or transporter dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for a range of disorders linked to ion channel dysfunction.
How similar studies have performed: Previous research has shown promise in understanding ion channel interactions, suggesting potential for breakthroughs in treatment.
Where this research is happening
Irvine, United States
- University of California-Irvine — Irvine, United States (Active)
Researchers
- Principal investigator: Abbott, Geoffrey W — University of California-Irvine
- Study coordinator: Abbott, Geoffrey W
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.