Investigating how ion channels in cell organelles function and their role in diseases.
Structural and Functional Studies of Organellar Ion Channels
This study is looking at special channels in our cells that help with important functions like sending signals in nerves and making muscles work, and it aims to learn more about how these channels in certain cell parts might be linked to health issues when they don't work properly.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project ID | NIH-11056010 on NIH RePORTER |
What this research studies
This research focuses on understanding the structure and function of ion channels located in cell organelles, which are crucial for various physiological processes such as nerve signaling and muscle contraction. The researchers aim to explore two specific types of organellar cation channels: those found in endolysosomes and mitochondrial calcium uniporters. By using advanced techniques to analyze these channels, the study seeks to uncover how they contribute to cell signaling and the regulation of cellular functions. This knowledge could lead to better insights into diseases caused by ion channel dysfunction.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from conditions related to ion channel dysfunction, such as cardiac arrhythmias or ataxia.
Not a fit: Patients with conditions unrelated to ion channel dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for conditions like arrhythmias and ataxia by targeting the underlying mechanisms of ion channel dysfunction.
How similar studies have performed: Previous research has shown success in understanding ion channels in plasma membranes, but the study of organellar ion channels is relatively novel and less explored.
Where this research is happening
Dallas, United States
- Ut Southwestern Medical Center — Dallas, United States (Active)
Researchers
- Principal investigator: Jiang, Youxing — Ut Southwestern Medical Center
- Study coordinator: Jiang, Youxing
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.