Investigating how Intralipid affects nerve function to treat local anesthetic toxicity
Official title: Metabolic impact of Intralipid on synaptic function as a mechanism of resuscitation in local anesthetic systemic toxicity
Funded at Weill Medical Coll of Cornell Univ · NIH-11010018 · Data updated 2026-11-12
This study is looking at how a special fat solution called Intralipid might help protect nerves from the harmful effects of local anesthetics, which can sometimes cause serious problems like seizures or heart issues, and it will involve patients to see if this treatment is safe and effective.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | February 1, 2023 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $194,400 |
| NIH project number | 5K08GM148935-03 |
| Project ID | NIH-11010018 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals who have experienced local anesthetic systemic toxicity or are at risk of such reactions during medical procedures.
✕Less likely to help
Patients who have not been exposed to local anesthetics or those with unrelated medical conditions may not benefit from this research.
What this research studies
This research explores the effects of intravenous lipid emulsions (ILEs), specifically Intralipid, on nerve function in the context of local anesthetic systemic toxicity (LAST). It aims to understand the mechanisms by which ILEs can reverse the toxic effects of local anesthetics that can lead to severe complications like seizures and cardiac arrest. The study will examine whether ILEs work by simply diluting the anesthetics in the bloodstream or if they provide metabolic support to nerve cells by serving as an energy source. Patients may be involved in trials to assess the efficacy and safety of this treatment approach.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment protocols for patients experiencing severe reactions to local anesthetics, potentially saving lives.
How similar studies have gone: Previous research has shown that intravenous lipid emulsions can be effective in treating local anesthetic toxicity, but the specific mechanisms remain under investigation.
Where this research is happening
-
Weill Medical Coll of Cornell Univ
New York, United States Active
Researchers
- Principal investigator: Cook, Daniel Charles — Weill Medical Coll of Cornell Univ
- Study coordinator: Cook, Daniel Charles
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.