Investigating how intestinal inflammation affects lung pressure in pulmonary hypertension
Role of intestinal inflammation in oxidized lipid induced pulmonary hypertension
This study is looking at how inflammation in the gut might lead to high blood pressure in the lungs, which can be really serious, and it's trying to find out if certain fatty acids play a role in this process, with the hope that what they learn could help develop new treatments for people with this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-11014950 on NIH RePORTER |
What this research studies
This research explores the connection between intestinal inflammation and pulmonary hypertension (PH), a serious lung condition. It focuses on how oxidized fatty acids, particularly a type called 15HETE, can lead to increased pressure in the lungs and heart failure. By studying mice on a specific diet, researchers aim to uncover the molecular mechanisms that cause this condition, particularly looking at the role of immune cells and specific genes involved in inflammation. The findings could provide insights into new treatment strategies for patients suffering from PH.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with pulmonary arterial hypertension or those experiencing related symptoms.
Not a fit: Patients with pulmonary hypertension not linked to intestinal inflammation or those with other unrelated lung conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic approaches for treating pulmonary hypertension, potentially improving patient outcomes.
How similar studies have performed: Other research has shown promising results in understanding the role of inflammation in pulmonary hypertension, suggesting that this approach could yield valuable insights.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Eghbali, Mansoureh — University of California Los Angeles
- Study coordinator: Eghbali, Mansoureh
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.