Investigating how interferon lambda affects gut health and inflammatory bowel disease in infants
Role of Interferon lambda signaling in mucosal homeostasis and infantile-onset inflammatory bowel disease
This study is looking at how a special immune signal called interferon lambda helps keep the gut healthy and how it might affect inflammatory bowel disease (IBD) in babies, especially those with certain genetic conditions, to better understand their health and improve their treatment.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10906130 on NIH RePORTER |
What this research studies
This research explores the role of interferon lambda in maintaining gut health and its potential impact on inflammatory bowel disease (IBD) in infants. The study focuses on understanding how immune signals, particularly interferon lambda, interact with the gut's microbiome and immune cells. By examining patients with rare genetic mutations affecting interferon lambda, the research aims to uncover how these factors contribute to IBD and how they may improve over time. The approach includes both laboratory studies and patient observations to gather comprehensive data.
Who could benefit from this research
Good fit: Ideal candidates for this research include infants and young children diagnosed with inflammatory bowel disease, particularly those with genetic mutations affecting interferon lambda.
Not a fit: Patients who are older than 21 or do not have inflammatory bowel disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for infants suffering from inflammatory bowel disease, improving their quality of life.
How similar studies have performed: While research on interferon lambda is relatively novel, preliminary findings suggest it may be effective in reducing intestinal inflammation, indicating potential for success.
Where this research is happening
Boston, United States
- Boston Children's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Ouahed, Jodie — Boston Children's Hospital
- Study coordinator: Ouahed, Jodie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.