Investigating how integrin tension affects cell movement and immune functions
Study the role of integrin tension in cell migration, platelet functions and phagocytosis
This study is looking at how the forces that help cells stick and move around can affect important processes like how our immune system fights off germs and how cancer spreads, with the hope of finding new ways to treat these conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Cincinnati NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project ID | NIH-11011055 on NIH RePORTER |
What this research studies
This research explores the role of integrin tension in various cellular processes, including how cells migrate, how platelets function, and how immune cells engulf pathogens. By using innovative tools like tension sensors and modulators, the study aims to visualize and manipulate the forces at play in live cells. This could lead to a better understanding of critical processes such as cancer metastasis and immune responses, which are vital for developing new therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with conditions related to cancer or immune system disorders.
Not a fit: Patients with stable, non-progressive conditions that do not involve cell migration or immune response may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in treating conditions related to cancer metastasis and immune dysfunction.
How similar studies have performed: Other research has shown promising results in understanding cellular mechanics and their implications in disease, suggesting that this approach could yield valuable insights.
Where this research is happening
Cincinnati, United States
- University of Cincinnati — Cincinnati, United States (Active)
Researchers
- Principal investigator: Wang, Xuefeng — University of Cincinnati
- Study coordinator: Wang, Xuefeng
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.