Investigating how insulin-like growth factor binding proteins affect herpes-related eye disease.
Role of insulin-like growth factor binding proteins in the pathogenesis of herpes stromal keratitis.
This study is looking at how a protein called IGFBP-3 affects herpes stromal keratitis, an eye condition caused by the herpes virus that can lead to blindness, with the goal of finding better treatments that might help patients avoid long-term steroid use.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wayne State University NIH-funded |
| Lab location | 1 site (Detroit, United States) |
| Project ID | NIH-10891477 on NIH RePORTER |
What this research studies
This research focuses on herpes stromal keratitis (HSK), a chronic eye condition caused by the herpes simplex virus that can lead to blindness. The study aims to understand the role of insulin-like growth factor binding protein-3 (IGFBP-3) in the disease's development and progression. By exploring both IGF-dependent and independent mechanisms, the researchers hope to identify new therapeutic targets that could improve treatment outcomes. Patients may benefit from insights that could lead to more effective therapies and reduced reliance on long-term steroid use.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from herpes stromal keratitis, particularly those experiencing recurrent infections.
Not a fit: Patients with other forms of corneal disease unrelated to herpes simplex virus may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that reduce the severity of herpes stromal keratitis and improve vision outcomes for patients.
How similar studies have performed: Previous research has shown promise in targeting similar pathways in other inflammatory conditions, suggesting potential for success in this area as well.
Where this research is happening
Detroit, United States
- Wayne State University — Detroit, United States (Active)
Researchers
- Principal investigator: Suvas, Susmit — Wayne State University
- Study coordinator: Suvas, Susmit
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.