Investigating how injury during organ transplantation affects immune response and transplant rejection
IRI, innate immunity and transplant rejection
This study is looking at how damage from blood flow returning to an organ after transplantation affects the immune system, which can lead to the body rejecting the new organ, and it aims to find ways to help improve the success and longevity of organ transplants for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11037912 on NIH RePORTER |
What this research studies
This research focuses on understanding the impact of ischemia reperfusion injury (IRI) on the immune response in patients undergoing organ transplantation. It aims to explore how IRI activates the innate immune system, leading to increased rates of both acute and chronic rejection of transplanted organs. The study will utilize advanced methodologies to analyze the mechanisms behind this process and evaluate potential therapeutic strategies to mitigate the negative effects of IRI on transplant outcomes. By addressing these critical issues, the research seeks to improve the longevity and success of organ transplants for patients.
Who could benefit from this research
Good fit: Ideal candidates for this research include patients who are undergoing or are candidates for organ transplantation.
Not a fit: Patients who are not candidates for organ transplantation or those with conditions that preclude them from receiving a transplant may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing transplant rejection, enhancing the longevity of transplanted organs.
How similar studies have performed: Previous research has shown promising results in understanding the role of IRI in transplant rejection, indicating that this area of investigation is both relevant and necessary.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Abdi, Reza — Brigham and Women's Hospital
- Study coordinator: Abdi, Reza
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.