Investigating how injuries affect immune cell function
Hematopoietic Stem and Progenitor Cell Dysfunction is an Underlying Mechanism of Injury-Inuced Immunosuppression
This study is looking at how serious illnesses and injuries can weaken the immune system by affecting certain blood cells, and it aims to find ways to help improve immune function for patients who are critically ill.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-10689711 on NIH RePORTER |
What this research studies
This research explores how critical illnesses and injuries can lead to immune dysfunction by affecting hematopoietic stem and progenitor cells (HSPC). The team will study changes in these cells and their impact on the immune response, using murine models to simulate human conditions. By understanding these mechanisms, the research aims to identify potential therapeutic targets to improve immune function in critically ill patients. The findings could help translate laboratory discoveries into clinical applications for better patient care.
Who could benefit from this research
Good fit: Ideal candidates for this research include patients who have experienced critical illnesses or severe injuries that may compromise their immune system.
Not a fit: Patients with stable chronic conditions that do not involve immune dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients suffering from immune dysfunction following critical illnesses or injuries.
How similar studies have performed: Previous research has shown that understanding the role of hematopoietic stem cells in immune responses can lead to significant advancements in treatment strategies, indicating a promising avenue for this investigation.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Turnbull, Isaiah R — Washington University
- Study coordinator: Turnbull, Isaiah R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.