Investigating how inhibitory synapses develop in the brain
Official title: Cellular and Molecular Mechanisms of Inhibitory Synapse Development
Funded at Brandeis University · NIH-11105836 · Data updated 2026-11-12
This study is looking at how certain molecules in the brain help create connections that keep our brain activity balanced, which is important for conditions like autism and epilepsy, to find new ways to help treat these issues.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brandeis University NIH-funded |
| Lab location | 1 site (Waltham, United States) |
| Project start | June 1, 2024 |
| Project end | May 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $35,300 |
| NIH project number | 5F31NS134188-02 |
| Project ID | NIH-11105836 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with autism spectrum disorder or other related neurological conditions.
✕Less likely to help
Patients with conditions unrelated to synaptic dysfunction may not benefit from this research.
What this research studies
This research focuses on understanding the cellular and molecular mechanisms that lead to the formation of inhibitory synapses in the brain, which are crucial for maintaining a balance between excitation and inhibition in neural circuits. By studying specific signaling molecules, particularly Semaphorin 4D, the research aims to uncover how these molecules influence synapse formation and their potential role in neurological disorders like autism and epilepsy. The approach involves examining the effects of these molecules on synapse development and their implications for treating conditions associated with synaptic imbalance.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating neurological disorders characterized by synaptic dysfunction.
How similar studies have gone: Previous research has shown promising results in understanding excitatory synapse formation, but the specific focus on inhibitory synapse development through Sema4D is relatively novel.
Where this research is happening
-
Brandeis University
Waltham, United States Active
Researchers
- Principal investigator: Pranske, Zachary James — Brandeis University
- Study coordinator: Pranske, Zachary James
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.