Investigating how inhibiting a specific enzyme may help treat Alzheimer's disease.
Vascular mechanisms of inhibition of sEH as a novel therapy for AD/ADRD
This study is looking at how a specific enzyme affects brain health in people with Alzheimer's and related dementias, and it’s testing whether blocking this enzyme can help improve thinking and blood flow in the brain, with the hope of finding better treatments for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Mississippi Med Ctr NIH-funded |
| Lab location | 1 site (Jackson, United States) |
| Project ID | NIH-10525694 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of vascular mechanisms in Alzheimer's disease and related dementias (AD/ADRD). It explores how inhibiting the enzyme soluble epoxide hydrolase (sEH) can improve cognitive function and brain blood flow in models of AD and diabetes-related dementia. The study involves analyzing genetic factors and the effects of a selective sEH inhibitor on brain health, aiming to uncover new therapeutic strategies for patients. By examining the relationship between inflammation, blood flow, and cognitive decline, the research seeks to provide insights into precision medicine for AD/ADRD.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or related dementias, particularly those with a history of diabetes.
Not a fit: Patients with other forms of dementia unrelated to Alzheimer's or those without cognitive impairment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options that improve cognitive function and brain health in patients with Alzheimer's disease.
How similar studies have performed: Previous studies have shown promising results with similar approaches targeting vascular mechanisms in Alzheimer's disease, indicating potential for success.
Where this research is happening
Jackson, United States
- University of Mississippi Med Ctr — Jackson, United States (Active)
Researchers
- Principal investigator: Roman, Richard J. — University of Mississippi Med Ctr
- Study coordinator: Roman, Richard J.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.