Investigating how inflammation outside the brain affects traumatic brain injury.
Role of Peripheral Inflammation in TBI Pathobiology
['FUNDING_R01'] · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · NIH-11016942
This study is looking at how inflammation from the body can affect healing after a traumatic brain injury (TBI) and is testing whether stimulating a nerve can help reduce that inflammation and improve recovery.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON (nih funded) |
| Locations | 1 site (HOUSTON, UNITED STATES) |
| Trial ID | NIH-11016942 on ClinicalTrials.gov |
What this research studies
This research explores the role of peripheral inflammation in the pathology of traumatic brain injury (TBI). It aims to understand how inflammation from outside the brain can contribute to further brain damage and neurodegeneration after a TBI. The study will utilize animal models to examine the effects of vagus nerve stimulation on reducing inflammation and improving outcomes. By focusing on the interaction between the nervous system and inflammatory responses, the research seeks to uncover new therapeutic targets for managing TBI.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced a traumatic brain injury and may be suffering from inflammation-related complications.
Not a fit: Patients with chronic neurological conditions unrelated to traumatic brain injury may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that mitigate brain damage and improve recovery outcomes for TBI patients.
How similar studies have performed: Previous studies have shown promising results in reducing inflammation through vagus nerve stimulation, indicating potential for success in this area of research.
Where this research is happening
HOUSTON, UNITED STATES
- UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON — HOUSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DASH, PRAMOD K — UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
- Study coordinator: DASH, PRAMOD K
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired brain injury