Investigating how inflammation in lung tissue affects aging immune cells
Official title: Role of stromal inflammatory signaling in the aging of lung resident lymphocytes
Funded at University of California, San Francisco · NIH-10907779 · Data updated 2026-11-12
This study is looking at how inflammation in the lung's supportive tissue affects the aging of immune cells, using young and older mice to find out what changes happen as we age, which could help us understand and treat lung diseases that come with getting older.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | August 15, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $169,020 |
| NIH project number | 5K08HL169723-02 |
| Project ID | NIH-10907779 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults experiencing lung-related health issues or age-related immune dysfunction.
✕Less likely to help
Patients who are young or do not have any lung diseases or immune system dysfunction may not benefit from this research.
What this research studies
This research explores the role of inflammatory signaling in the lung's supportive tissue and how it impacts the aging of immune cells. By comparing lung tissue from young and aged mice, researchers aim to identify changes that contribute to immune dysfunction associated with age. The study utilizes advanced techniques like single-cell RNA sequencing to analyze the molecular changes in lung mesenchyme and their effects on immune responses. This could lead to a better understanding of age-related lung diseases and potential therapeutic targets.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for age-related lung diseases by improving immune function in older adults.
How similar studies have gone: Other research has shown promising results in understanding the role of the tissue microenvironment in immune system aging, suggesting this approach could yield valuable insights.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Allen, Nancy Christine — University of California, San Francisco
- Study coordinator: Allen, Nancy Christine
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.