Investigating how inflammation in breast fat affects breast cancer outcomes
Breast White Adipose Tissue Inflammation and Breast Cancer Outcomes
This study is looking at how inflammation in fat tissue around the breast might affect the outcomes of breast cancer, especially in women who are dealing with obesity and related health issues, to see if certain markers can help us understand cancer progression and recurrence better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Kaiser Foundation Research Institute NIH-funded |
| Lab location | 1 site (Oakland, UNITED STATES) |
| Project ID | NIH-10837832 on NIH RePORTER |
What this research studies
This research explores the relationship between inflammation in breast white adipose tissue and breast cancer outcomes. It focuses on a specific inflammatory biomarker known as crown-like structures of the breast (CLS-B), which indicates a state of inflammation linked to obesity and metabolic issues. By analyzing data from a diverse cohort of women diagnosed with breast cancer, the study aims to uncover how these inflammatory markers influence cancer progression and recurrence. Patients may be monitored for their adipose tissue characteristics and how these relate to their cancer outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are women diagnosed with invasive breast cancer, particularly those who are overweight or obese.
Not a fit: Patients who are not diagnosed with breast cancer or those with a healthy weight may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for managing breast cancer in patients with obesity, potentially reducing recurrence rates and improving survival.
How similar studies have performed: Previous research has indicated that inflammation in adipose tissue is linked to cancer outcomes, suggesting that this approach may yield valuable insights.
Where this research is happening
Oakland, UNITED STATES
- Kaiser Foundation Research Institute — Oakland, United States (Active)
Researchers
- Principal investigator: Kushi, Lawrence H — Kaiser Foundation Research Institute
- Study coordinator: Kushi, Lawrence H
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.