Investigating how inflammation differs between sexes as people age
Official title: Sex Differences in Inflammation Across the Lifespan
Funded at University of Texas Hlth Sci Ctr Houston · NIH-11083037 · Data updated 2026-11-12
This study looks at how men and women respond differently to inflammation throughout their lives, especially after a stroke, to find out how these differences can help create better treatments for recovery and improve life after a stroke for everyone.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Sci Ctr Houston NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | May 1, 2023 |
| Project end | April 30, 2031 |
| Funding year | 2025 |
| Award (this year) | $1,170,000 |
| NIH project number | 5R35NS132265-03 |
| Project ID | NIH-11083037 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals who have experienced a stroke, particularly elderly men and women.
✕Less likely to help
Patients who have not had a stroke or are not experiencing age-related inflammatory conditions may not benefit from this research.
What this research studies
This research explores the differences in inflammatory responses between men and women throughout their lives, particularly in relation to stroke outcomes. It examines how biological factors, such as sex chromosomes and hormonal changes, influence inflammation and recovery after stroke. By studying these differences in various tissues, including the brain and adipose tissue, the research aims to uncover the mechanisms behind these disparities. Ultimately, the goal is to develop targeted therapies that can improve recovery and quality of life for both men and women after a stroke.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve recovery and reduce disability after stroke for both men and women.
How similar studies have gone: Previous research has shown promising results in understanding sex differences in inflammation and recovery, suggesting that this approach could lead to significant advancements in treatment.
Where this research is happening
-
University of Texas Hlth Sci Ctr Houston
Houston, United States Active
Researchers
- Principal investigator: Mccullough, Louise D. — University of Texas Hlth Sci Ctr Houston
- Study coordinator: Mccullough, Louise D.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.