Investigating how inflammation contributes to stomach cancer development
The role of type 2 inflammation in the initiation and progression of metaplastic differentiation and neoplastic transformation of gastric epithelia
['FUNDING_R01'] · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · NIH-10977336
This study is looking at how long-term stomach inflammation might lead to stomach cancer, especially in people with certain conditions, and it wants to help patients understand their genetic risks and how inflammation impacts their stomach health.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MIAMI SCHOOL OF MEDICINE (nih funded) |
| Locations | 1 site (CORAL GABLES, UNITED STATES) |
| Trial ID | NIH-10977336 on ClinicalTrials.gov |
What this research studies
This research explores the connection between chronic inflammation in the stomach and the progression of gastric cancer. It focuses on how conditions like atrophic gastritis and metaplasia can lead to the development of gastric adenocarcinoma. By studying genetic factors and the role of H. pylori infection, the research aims to uncover the mechanisms behind these transformations. Patients may be involved in understanding their genetic predispositions and how inflammation affects their gastric health.
Who could benefit from this research
Good fit: Ideal candidates include individuals with a history of chronic stomach inflammation or those with genetic predispositions to gastric cancer.
Not a fit: Patients without any history of gastric inflammation or genetic risk factors for gastric cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better prevention and treatment strategies for gastric cancer.
How similar studies have performed: Previous research has shown promising results in understanding the role of inflammation in cancer development, suggesting that this approach could yield valuable insights.
Where this research is happening
CORAL GABLES, UNITED STATES
- UNIVERSITY OF MIAMI SCHOOL OF MEDICINE — CORAL GABLES, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHEN, ZHIBIN — UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
- Study coordinator: CHEN, ZHIBIN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.