Investigating how inflammation contributes to bleeding within atherosclerotic plaques
Role of inflammation in intraplaque hemorrhage pathogenesis
This study is looking at how inflammation in your blood vessels can lead to serious heart problems, and it aims to find new ways to treat these issues beyond just lowering cholesterol, using advanced imaging techniques to better understand your heart health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-11076264 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of inflammation in the development of intraplaque hemorrhage, which is a significant factor in the progression of atherosclerotic cardiovascular disease (ASCVD). By examining the relationship between plaque neovascularization and inflammatory cells, the study aims to identify new treatment strategies that go beyond traditional cholesterol-lowering therapies. Patients may benefit from advanced imaging techniques and insights into how inflammation affects their cardiovascular health, potentially leading to more effective treatments. The research employs dynamic contrast-enhanced magnetic resonance imaging to assess plaque characteristics and their implications for patient outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with atherosclerotic cardiovascular disease who are at risk for plaque instability.
Not a fit: Patients without atherosclerotic cardiovascular disease or those who do not exhibit signs of plaque instability may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that significantly reduce the risk of heart attacks and strokes in patients with atherosclerosis.
How similar studies have performed: Previous studies have shown promising results in understanding the role of inflammation in atherosclerosis, suggesting that this approach could lead to significant advancements in treatment.
Where this research is happening
Seattle, United States
- University of Washington — Seattle, United States (Active)
Researchers
- Principal investigator: Kim, Francis — University of Washington
- Study coordinator: Kim, Francis
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.