Investigating how inflammation at the maternal-fetal interface affects fetal immune development
Official title: Sterile Inflammation at the Maternal-Fetal Interface and Fetal Immune Programming in a Non-Human Primate Model
Funded at University of Wisconsin-Madison · NIH-10864406 · Data updated 2026-11-12
This study is looking at how inflammation in the placenta affects the baby's immune system during pregnancy, and it's for expecting parents who want to know more about how these changes might impact their child's health.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project start | August 21, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $219,456 |
| NIH project number | 1K01AI182448-01 |
| Project ID | NIH-10864406 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research would include pregnant individuals, particularly those in the second or third trimester, who may be at risk for complications related to immune system development.
✕Less likely to help
Patients who are not pregnant or those whose pregnancies are not at risk for immune-related complications may not benefit from this research.
What this research studies
This research explores the impact of localized inflammation at the maternal-fetal interface on the developing immune system of the fetus. By injecting a clotting agent into the placental area of pregnant rhesus macaques, researchers aim to create a controlled inflammatory environment to study its effects. The goal is to understand how this inflammation influences the fetal immune response and to identify potential therapeutic interventions that could be applied either during pregnancy or after birth. The findings could lead to new strategies for managing immune-related conditions in children.
Why it matters
Potential benefit: If successful, this research could lead to targeted therapies that improve fetal immune development and reduce the risk of immune-related disorders in children.
How similar studies have gone: While the specific approach of this research is novel, previous studies have shown that understanding maternal immune responses can significantly impact fetal health outcomes.
Where this research is happening
-
University of Wisconsin-Madison
Madison, United States Active
Researchers
- Principal investigator: Vazquez, Jessica — University of Wisconsin-Madison
- Study coordinator: Vazquez, Jessica
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.