Investigating how inflammation and alcohol use affect cognitive decline in people with HIV
Official title: Longitudinal Modeling of Pro-Inflammatory Cytokines, Hazardous Alcohol Use, and Cerebral Metabolites as Predictors of Neurocognitive Change in People with HIV
Funded at University of Florida · NIH-11009938 · Data updated 2026-11-12
This study is looking at how inflammation and heavy drinking might affect thinking skills in people living with HIV, using blood tests and mental performance over time to see if inflammation can help predict changes in their cognitive health.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project start | January 1, 2024 |
| Project end | December 31, 2025 |
| Funding year | 2025 |
| Award (this year) | $41,883 |
| NIH project number | 5F31AA031440-02 |
| Project ID | NIH-11009938 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults living with HIV who may also have a history of heavy alcohol use.
✕Less likely to help
Patients who are not living with HIV or do not have issues related to alcohol use may not benefit from this research.
What this research studies
This research examines the relationship between systemic inflammation, alcohol use, and cognitive decline in individuals living with HIV. By analyzing blood plasma markers and cognitive performance over time, the study aims to understand how changes in inflammation may predict cognitive changes. The approach involves a secondary analysis of existing data from a cohort of adults with HIV, focusing on the impact of heavy alcohol use on cognitive health. The findings could provide insights into the mechanisms behind cognitive deficits in this population.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and potential interventions to mitigate cognitive decline in people living with HIV.
How similar studies have gone: Other research has shown promising results in understanding the links between inflammation and cognitive decline in HIV, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Florida
Gainesville, United States Active
Researchers
- Principal investigator: Britton, Mark K — University of Florida
- Study coordinator: Britton, Mark K
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.