Investigating how inflammation affects the microbiome in laryngeal scarring after intubation
Official title: Inflammatory mechanisms of dysbiosis in laryngeal glottic stenosis
Funded at University of Wisconsin-Madison · NIH-11113628 · Data updated 2026-11-12
This study is looking at how injuries to the voice box from intubation can cause inflammation and affect healing, and it aims to find ways to help patients recover better after such injuries.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project start | May 1, 2025 |
| Project end | April 30, 2030 |
| Funding year | 2025 |
| Award (this year) | $142,074 |
| NIH project number | 1K23DC022677-01 |
| Project ID | NIH-11113628 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced acute laryngeal injury due to intubation and are suffering from related complications.
✕Less likely to help
Patients who have not undergone intubation or do not have laryngeal injuries may not benefit from this research.
What this research studies
This research focuses on understanding the inflammatory processes that occur in the larynx following acute laryngeal injury, which often happens after intubation. By analyzing the microbiome through advanced sequencing techniques, the study aims to identify how microbial changes contribute to scarring and dysfunction in the larynx. The goal is to uncover the mechanisms behind impaired healing and develop targeted therapies to improve patient outcomes. Patients who have experienced intubation-related injuries may provide valuable insights into these processes.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance healing and restore voice and breathing function for patients with laryngeal scarring.
How similar studies have gone: Previous research has shown promising results in understanding microbial influences on healing in similar contexts, suggesting potential for success in this novel approach.
Where this research is happening
-
University of Wisconsin-Madison
Madison, United States Active
Researchers
- Principal investigator: Davis, Ruth Jennifer — University of Wisconsin-Madison
- Study coordinator: Davis, Ruth Jennifer
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.