Investigating how inflammation affects stomach cell changes that can lead to cancer
Official title: The Role of Inflammation in Regulating Gastric Metaplasia
Funded at Saint Louis University · NIH-11000847 · Data updated 2026-11-12
This study is looking at how long-lasting inflammation from infections and autoimmune issues can change stomach cells in ways that might lead to cancer, and it's aimed at helping people who are at risk for gastric cancer by finding better ways to spot and treat these changes early.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Saint Louis University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | March 1, 2023 |
| Project end | December 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $484,531 |
| NIH project number | 5R01DK134531-03 |
| Project ID | NIH-11000847 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with chronic inflammation of the stomach, such as those infected with Helicobacter pylori or diagnosed with autoimmune gastritis.
✕Less likely to help
Patients without chronic stomach inflammation or those not at risk for gastric cancer may not benefit from this research.
What this research studies
This research explores the mechanisms by which chronic inflammation, particularly from infections like Helicobacter pylori and autoimmune gastritis, leads to precancerous changes in stomach cells. Using mouse models and human tissue samples, the study focuses on the role of specific immune cells and cytokines in the development of gastric metaplasia, a condition that can progress to cancer. By identifying the inflammatory signals that trigger these changes, the research aims to enhance early detection and develop new treatment strategies for individuals at risk of gastric cancer.
Why it matters
Potential benefit: If successful, this research could lead to improved methods for identifying and treating individuals at high risk for gastric cancer.
How similar studies have gone: Previous research has shown promising results in understanding the role of inflammation in cancer development, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Saint Louis University
Saint Louis, United States Active
Researchers
- Principal investigator: Dipaolo, Richard J — Saint Louis University
- Study coordinator: Dipaolo, Richard J
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.