Investigating how inflammation affects stomach cell changes and cancer development
The role of type 2 inflammation in the initiation and progression of metaplastic differentiation and neoplastic transformation of gastric epithelia
This study is looking at how long-term inflammation in the stomach might change stomach cells and lead to gastric cancer, especially focusing on a gene called CTLA4, to find ways to spot and treat the cancer early, particularly for patients with certain genetic traits.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Miami School of Medicine NIH-funded |
| Lab location | 1 site (Coral Gables, United States) |
| Project ID | NIH-10853131 on NIH RePORTER |
What this research studies
This research explores the connection between chronic inflammation in the stomach and the transformation of stomach cells that can lead to gastric cancer. It focuses on understanding how certain genetic factors, particularly related to the CTLA4 gene, may influence this process. By studying both human cases and animal models, the research aims to identify potential biomarkers and therapeutic targets that could help in early detection and treatment of gastric cancer. Patients with specific genetic predispositions may be particularly relevant to this investigation.
Who could benefit from this research
Good fit: Ideal candidates for participation would include individuals with a history of chronic stomach inflammation or genetic predispositions related to gastric cancer.
Not a fit: Patients without chronic stomach inflammation or those not genetically predisposed to gastric cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved methods for early detection and treatment of gastric cancer, potentially saving lives.
How similar studies have performed: Previous research has shown promising results in understanding the role of inflammation and genetic factors in cancer development, suggesting that this approach may yield valuable insights.
Where this research is happening
Coral Gables, United States
- University of Miami School of Medicine — Coral Gables, United States (Active)
Researchers
- Principal investigator: Chen, Zhibin — University of Miami School of Medicine
- Study coordinator: Chen, Zhibin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.