Investigating how inflammation affects sleep regulation in aging
Preoptic/Hypothalamic Mechanisms of Sleep-Wake Regulation
This study looks at how inflammation affects sleep, especially as we get older, by examining specific parts of the brain that control our sleep patterns, with the goal of finding ways to help older adults sleep better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | VA Greater Los Angeles Healthcare System NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-11053930 on NIH RePORTER |
What this research studies
This research explores the mechanisms by which inflammation impacts sleep regulation, particularly in the context of aging. It focuses on the preoptic and hypothalamic regions of the brain, which are crucial for sleep-wake cycles. By studying the effects of chronic inflammation on these brain areas in animal models, the research aims to understand how such changes may lead to sleep disturbances commonly seen in older adults. The findings could help identify potential therapeutic targets for improving sleep quality in the elderly.
Who could benefit from this research
Good fit: Ideal candidates for this research are elderly individuals, particularly those experiencing chronic sleep disturbances or related health issues.
Not a fit: Patients who are not elderly or do not have sleep disturbances may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for sleep disorders in older adults, improving their overall health and quality of life.
How similar studies have performed: Previous research has shown that inflammation can disrupt sleep patterns, suggesting that this approach may yield valuable insights.
Where this research is happening
Los Angeles, United States
- VA Greater Los Angeles Healthcare System — Los Angeles, United States (Active)
Researchers
- Principal investigator: Alam, Noor — VA Greater Los Angeles Healthcare System
- Study coordinator: Alam, Noor
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.