Investigating how inflammation affects pulmonary hypertension
Role of Complement-Driven Pulmonary Vascular Inflammation in PH
This study is looking at how inflammation caused by autoimmune diseases and infections might lead to pulmonary hypertension, and it's for anyone who wants to understand how immune cells affect this condition and what new treatments might be developed to help.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-10911063 on NIH RePORTER |
What this research studies
This research explores the role of inflammation in pulmonary hypertension (PH), particularly how it is triggered by autoimmune diseases and infections like schistosomiasis. The team aims to understand the complex interactions between different immune cells, including monocytes and T cells, and how these contribute to the vascular changes seen in PH. By studying these mechanisms, the researchers hope to identify potential therapeutic targets that could lead to new treatments for patients suffering from this condition.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with pulmonary hypertension, particularly those with autoimmune conditions or schistosomiasis.
Not a fit: Patients with pulmonary hypertension not related to autoimmune diseases or schistosomiasis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that effectively reduce inflammation and improve outcomes for patients with pulmonary hypertension.
How similar studies have performed: Previous research has shown that targeting inflammation can prevent pulmonary hypertension in pre-clinical models, indicating a promising avenue for further exploration.
Where this research is happening
Aurora, UNITED STATES
- University of Colorado Denver — Aurora, United States (Active)
Researchers
- Principal investigator: Graham, Brian Barkley — University of Colorado Denver
- Study coordinator: Graham, Brian Barkley
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.