Investigating how inflammation affects pain in osteoarthritis
Modulation of Inflammation in Osteoarthritis via CD14-mediated pattern recognition
This study is looking at how a specific protein called CD14 affects inflammation and pain in osteoarthritis, using mice to find new ways to help people with this condition feel better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10669024 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of CD14, an inflammatory receptor, in the progression of osteoarthritis (OA) and its associated pain. By studying mice, the researchers aim to identify how CD14 influences inflammation and pain pathways in OA. The goal is to uncover new therapeutic targets that could lead to effective treatments for OA, which currently lacks effective medical interventions. Patients may benefit from insights gained about the molecular mechanisms driving their condition, potentially leading to new therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from osteoarthritis, particularly those experiencing chronic joint pain.
Not a fit: Patients with osteoarthritis who do not have significant inflammation or those with advanced joint degeneration may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that effectively reduce pain and slow the progression of osteoarthritis.
How similar studies have performed: Previous research has shown that targeting inflammatory pathways can lead to significant improvements in pain management for osteoarthritis, suggesting a promising avenue for this study.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Scanzello, Carla Rose — University of Pennsylvania
- Study coordinator: Scanzello, Carla Rose
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.