Investigating how inflammation affects oral bacteria and gum disease
Official title: From Symbiosis to Dysbiosis and Back: The Impact of Pro-Inflammation and Pro-Resolution
Funded at Ada Forsyth Institute, INC. · NIH-11030268 · Data updated 2026-11-12
This study is looking at how certain bacteria in your mouth affect your immune system when you have gum disease, and it will test if a special molecule can help reduce inflammation and bring everything back to normal.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ada Forsyth Institute, INC. NIH-funded |
| Lab location | 1 site (Cambridge, United States) |
| Project start | February 6, 2024 |
| Project end | January 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $164,700 |
| NIH project number | 5K99DE032048-02 |
| Project ID | NIH-11030268 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults over 21 years old who are experiencing symptoms of periodontitis or related gum diseases.
✕Less likely to help
Patients with non-inflammatory oral conditions or those under 21 years old may not benefit from this research.
What this research studies
This research focuses on understanding the relationship between oral bacteria and the immune response in periodontitis, a serious gum disease. It aims to explore how inflammation disrupts the balance between the body's tissues and the bacteria in the mouth, leading to disease. The study will investigate the role of specialized molecules called Resolvin E1 in reversing inflammation and restoring balance. By using animal models, researchers will test whether activating these molecules can prevent or treat periodontal dysbiosis, which is the imbalance of bacteria in the mouth.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for periodontitis that restore healthy bacterial balance and reduce inflammation.
How similar studies have gone: Previous research has shown promise in using specialized pro-resolving mediators to manage inflammation, suggesting potential success for this approach.
Where this research is happening
-
Ada Forsyth Institute, INC.
Cambridge, United States Active
Researchers
- Principal investigator: Yu, Ning — Ada Forsyth Institute, INC.
- Study coordinator: Yu, Ning
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.