Investigating how inflammation affects long-lived CD8 T cells in the immune system
Official title: Determining factors of inflammation that support the expansion and function of long-lived effector cell CD8 T cells in a mature memory compartment
Funded at University of Minnesota · NIH-10902637 · Data updated 2026-11-12
This study is looking at how inflammation and exposure to germs affect the long-lasting immune cells that help our bodies remember and fight off infections, and it's designed to help improve treatments for people with immune-related conditions.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $81,256 |
| NIH project number | 1F32AI178962-01A1 |
| Project ID | NIH-10902637 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions that could benefit from improved T cell responses, particularly those undergoing immunotherapy.
✕Less likely to help
Patients with conditions unrelated to immune function or those who are not candidates for immunotherapy may not benefit from this research.
What this research studies
This research explores the role of inflammation and pathogen exposure in the development and function of long-lived effector CD8 T cells, which are crucial for immune memory. By using a unique approach that involves exposing mice to various pathogens, the study aims to better mimic the human immune response. The researchers will identify specific cytokines and factors that promote the growth and maintenance of these important immune cells, potentially leading to improved immunotherapies. The findings could enhance our understanding of how the immune system adapts and functions in real-world conditions.
Why it matters
Potential benefit: If successful, this research could lead to more effective immunotherapies for various diseases by enhancing the function of long-lived T cells.
How similar studies have gone: Previous research has shown promising results in understanding T cell dynamics through similar approaches, indicating potential for success in this study.
Where this research is happening
-
University of Minnesota
Minneapolis, United States Active
Researchers
- Principal investigator: Lucas, Erin D — University of Minnesota
- Study coordinator: Lucas, Erin D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.