Investigating how inflammation affects immune responses in acute myeloid leukemia
The role of inflammation in the regulation of immune response in acute myeloid leukemia
This study is looking at how inflammation affects people with acute myeloid leukemia (AML) and whether reducing inflammation can help improve their treatment results and survival, so they can better understand what makes inflammation high and how it changes during treatment.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10883702 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of inflammation in acute myeloid leukemia (AML) and how it impacts patient outcomes. By studying a large cohort of AML patients, the researchers aim to identify the contributors to high inflammation levels in the bone marrow and how these levels change during standard treatments. They will explore whether targeting inflammation can enhance treatment responses and improve survival rates for patients. The study combines clinical data with advanced techniques to analyze the inflammatory state and its effects on leukemia progression.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older diagnosed with acute myeloid leukemia.
Not a fit: Patients with other types of leukemia or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for AML patients by targeting inflammation, potentially enhancing survival rates.
How similar studies have performed: Previous research has shown promising results in targeting inflammation in other cancers, suggesting potential success for this approach in AML.
Where this research is happening
New York, United States
- New York University School of Medicine — New York, United States (Active)
Researchers
- Principal investigator: Aifantis, Iannis — New York University School of Medicine
- Study coordinator: Aifantis, Iannis
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.