Investigating how inflammation affects immune responses in acute myeloid leukemia
Official title: The role of inflammation in the regulation of immune response in acute myeloid leukemia
Funded at New York University School of Medicine · NIH-10883702 · Data updated 2026-11-12
This study is looking at how inflammation affects people with acute myeloid leukemia (AML) and whether reducing inflammation can help improve their treatment results and survival, so they can better understand what makes inflammation high and how it changes during treatment.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | July 6, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $543,631 |
| NIH project number | 5R01CA283574-02 |
| Project ID | NIH-10883702 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults aged 21 and older diagnosed with acute myeloid leukemia.
✕Less likely to help
Patients with other types of leukemia or those under 21 years old may not benefit from this research.
What this research studies
This research focuses on understanding the role of inflammation in acute myeloid leukemia (AML) and how it impacts patient outcomes. By studying a large cohort of AML patients, the researchers aim to identify the contributors to high inflammation levels in the bone marrow and how these levels change during standard treatments. They will explore whether targeting inflammation can enhance treatment responses and improve survival rates for patients. The study combines clinical data with advanced techniques to analyze the inflammatory state and its effects on leukemia progression.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for AML patients by targeting inflammation, potentially enhancing survival rates.
How similar studies have gone: Previous research has shown promising results in targeting inflammation in other cancers, suggesting potential success for this approach in AML.
Where this research is happening
-
New York University School of Medicine
New York, United States Active
Researchers
- Principal investigator: Aifantis, Iannis — New York University School of Medicine
- Study coordinator: Aifantis, Iannis
Related research
Other NIH-funded projects on the same topics.
-
Targeting the SCP4 pathway in acute myeloid leukemia (AML)
Aims to uncover how the SCP4 signaling pathway drives AML and how it could be blocked to help patients.
-
Interferon-γ plus donor immune cells to fight AML/MDS after partial donor transplant
This project tests a therapy that adds a signaling protein, IFN-γ, with donor immune cells to help treat relapsed AML/MDS after a haploidentical stem cell transplant.
-
Targeting the protein housekeeping system in adult leukemia
Researchers are testing a new approach to treat acute myeloid leukemia by disrupting how AML cells manage their proteins, with the goal of helping patients live longer and healthier lives.
-
Understanding how epigenetic helper proteins drive AML and how to target them
A scientist team is studying how accessory proteins in gene-regulating complexes affect acute myeloid leukemia and whether they can be targeted for safer, more precise therapies.
-
Targeting FLVCR1-enabled choline use in a aggressive AML subtype
A new approach aims to block how a specific leukemia subtype (CG-AML) takes up choline to feed its growth, potentially slowing or stopping the disease.
-
Advancing CD70-targeted CAR-NK Therapy for AML
A patient-focused look at a new cell therapy that uses engineered NK cells to target AML by hitting CD70, aiming to reduce relapse with potentially fewer blood cell problems.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.