Investigating how inflammation affects heart rhythm in diabetes patients
Official title: Resolution of inflammation and atrial fibrillation
Funded at University of Minnesota · NIH-11020994 · Data updated 2026-11-12
This study is looking at how inflammation affects people with diabetes who have atrial fibrillation (AF) and is trying to find ways to lower the risk of AF by adjusting certain enzymes and boosting the body's natural defenses against inflammation.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project start | April 20, 2023 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $647,619 |
| NIH project number | 5R01HL165704-03 |
| Project ID | NIH-11020994 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients with diabetes who are at risk of developing atrial fibrillation.
✕Less likely to help
Patients without diabetes or those who do not have a history of atrial fibrillation may not benefit from this research.
What this research studies
This research focuses on understanding the role of inflammation in atrial fibrillation (AF), particularly in patients with diabetes. It examines how certain enzymes and signaling molecules contribute to inflammation and AF risk. By manipulating these factors, the study aims to find ways to reduce the risk of AF in diabetic patients. The approach includes testing the effects of inhibiting specific enzymes and enhancing the body's natural anti-inflammatory signals.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly lower the risk of atrial fibrillation in patients with diabetes.
How similar studies have gone: Previous research has shown promise in targeting inflammation to manage heart rhythm disorders, suggesting that this approach could be effective.
Where this research is happening
-
University of Minnesota
Minneapolis, United States Active
Researchers
- Principal investigator: Dudley, Samuel C — University of Minnesota
- Study coordinator: Dudley, Samuel C
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.